Comparative evaluation of 2 g single dose versus conventional dose azithromycin in uncomplicated skin and skin structure infections

Moxifloxacin versus Levofloxacin for Uncomplicated Skin and Skin Structure Infections: Treatment Durations, Failures, and Charges

• Objective: The approved therapy durations for the once-daily fluoroquinolones moxifloxacin and levofloxacin are 7 days and 7 to 10 days, respectively. We studied whether these labeling differences translated into differences in treatment duration, failure rates, or treatment charges in the treatment of uncomplicated skin and structure infections. • Design: Retrospective database study of insu...

Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections.

BACKGROUND Skin and skin-structure infections are common in ambulatory settings. However, the efficacy of various antibiotic regimens in the era of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is unclear. METHODS We enrolled outpatients with uncomplicated skin infections who had cellulitis, abscesses larger than 5 cm in diameter (smaller for younger children), or both...

Calculation of air gaps between bolus and skin on the dose received from the skin

    Introduction: In the last few decades, a lot of monte carlo codes have been introduced for medical applications. For close - to - surface tumors, the surface of the skin can be used to increase the surface dose so that all or part of the bunch area can fall into bolus, thereby increasing the dose of the skin. The air gaps between bolus and skin can affect the dose of...

Single-dose azithromycin for trachoma.

Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models.

OBJECTIVES As a result of the prolonged half-life and unique pharmacokinetic and pharmacodynamic (PK-PD) characteristics of azithromycin, shorter dosing regimens are being evaluated for the treatment of community-acquired infections. To provide further support for a shorter dosing regimen, the efficacy of azithromycin was determined in preclinical infection models comparing single- versus multi...